De Leon sustained a right flexor muscle strain while warming up in the top of the eighth inning of Minnesota’s 3-2 loss to the host Detroit Tigers on Saturday.
The 30-year-old is 0-1 with a 4.67 ERA in 12 games (one start) this season with the Twins.
Winder, 26, who was optioned to the Saints on June 17, is 1-0 with a 5.79 ERA in three relief appearances with Minnesota this season. He is 5-2 with two saves and a 5.14 ERA in 16 relief appearances in the minors in 2023.
Twins put RHP Jose De Leon on IL with flexor muscle strain