Burnley, managed by City legend Vincent Kompany, is the opening game of the season on Friday, Aug. 11.
Kenilworth Road will become the smallest ground to host a Premier League fixture when Luton play Burnley on Aug. 19.
Spurs face a difficult end to their season with consecutive games against Newcastle, Man City, Arsenal and Liverpool in April and May.
Newcastle United face a tricky start to their season, playing five of last season’s top eight in their first five fixtures. They open at home to Aston Villa before facing Man City (a), Liverpool (h), Brighton (a) and Brentford (h)
The first Manchester derby of the season will be played on Oct. 28 at Old Trafford and the reverse fixture at the Etihad takes place on March 2 with Guardiola’s side travelling to Anfield the following weekend on March 9.
Last season’s top two first meet on Oct. 7 in north London with Mikel Arteta’s side facing Man City in the reverse fixture on March 30.
Pochettino’s Chelsea rebuild will face a challenge in November with a return to former club Tottenham on Nov. 4, followed by fixtures against Man City (h) and Newcastle (a).
Premier League fixtures: Man City start title defence at Burnley, Chelsea host Liverpool in Pochettino’s first game