The Kansas City Chiefs have placed running back Clyde Edwards-Helaire on injured reserve, coach Andy Reid said Wednesday.

Edwards-Helaire suffered a high ankle sprain in the Chiefs’ 30-27 victory over the Los Angeles Chargers on Sunday night. He will have to miss at least four games before he will be eligible to return.

He is second on the team this season with 302 rushing yards and leads the team with three rushing touchdowns. He also has three touchdown receptions.

Rookie Isiah Pacheco leads the Chiefs with 386 rushing yards but hasn’t been as much of a factor in the passing game, with just three receptions for 13 yards. Edwards-Helaire has 17 receptions for 151 yards.

Other running backs on the Chiefs’ depth chart at the position are veterans Jerick McKinnon and Ronald Jones.

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Chiefs RB Clyde Edwards-Helaire to IR with high ankle sprain